Weight loss injections are becoming an increasingly popular option for people in the UK who are struggling to manage their weight. These treatments, including medications such as semaglutide and liraglutide, work by reducing your appetite and helping you feel full sooner, making it easier to eat less and lose weight over time. At C&H Barton Pharmacy in Bedfordshire, we want to help you understand your options and make the best choices for your health.

Want to know if weight loss injections could be right for you? Get in touch with our friendly pharmacy team in Bedfordshire, and we will be happy to help.

Key Takeaways

–> Weight loss injections such as semaglutide (Wegovy, Ozempic) and liraglutide (Saxenda) are clinically approved treatments for obesity and weight management.

–> They work by mimicking gut hormones that tell your brain you are full, which helps reduce how much you eat.

–> Clinical trials show that people can lose 10–15% or more of their body weight when using these injections alongside a healthy diet and exercise.

–> These treatments are not a quick fix as they are designed for long-term use and work best alongside healthier eating and more activity.

–> Side effects are common at the start, and usually include nausea, vomiting, and an upset stomach.

–> NHS access is limited as there are eligibility requirements, and waiting times can be long, though private options exist.

What Are Weight Loss Injections?

Weight loss injections are a type of medicine that was originally created to treat type 2 diabetes. Doctors noticed that people taking these medicines were also losing weight, and further research confirmed they could be used specifically for weight management too. The most widely used in the UK are semaglutide, sold as Wegovy for weight loss and Ozempic for diabetes. You also have liraglutide, sold as Saxenda for weight loss and Victoza for diabetes.

You use them with a small injection pen, either once a week (semaglutide) or once a day (liraglutide). They are used alongside a healthy diet and regular exercise. These medicines are recognised by NHS England for weight management, and there is strong clinical evidence behind how well they work.

do weight loss injections work

How Do Weight Loss Injections Work?

These injections copy a hormone your body naturally releases after you eat. This hormone, called GLP-1, tells your brain that you are full and slows down how quickly your stomach empties. When you take one of these medicines, you feel full sooner, your appetite drops, and you naturally eat less. Over time, this leads to steady weight loss.

Unlike fad diets, these injections work with your body rather than against it, which is why many people find them easier to stick to. That said, they are not a replacement for eating well and staying active, as they work best as part of an overall plan to improve your health.

Comparing the Main Weight Loss Injections Available in the UK
Medication Brand Name Injection Frequency Avg. Weight Loss NHS Availability
Semaglutide Wegovy Once weekly ~15% body weight Limited (specialist referral)
Liraglutide Saxenda Once daily ~8% body weight Limited (specialist referral)
Tirzepatide Mounjaro Once weekly Up to 22% body weight Increasingly available
Exenatide Byetta / Bydureon Twice daily / weekly Modest Primarily for type 2 diabetes

Still confused about which weight-loss injection to choose? Use our detailed comparison guide to the best weight-loss injections to make the right decision.

Who Can Get Weight Loss Injections in the UK?

On the NHS, eligibility depends on which medicine is being considered, and the criteria differ between the two main options.

Semaglutide (Wegovy) can only be prescribed through a specialist weight management service. You may be eligible if you have a BMI of 35 or above (or 32.5 or above if you are of Asian, Chinese, Middle Eastern, Black African, or African-Caribbean origin), alongside weight-related health problems. Those with a BMI of 30 to 34.9 (or 27.5 to 32.4 for the ethnic groups above) may also qualify if they meet additional criteria set by their specialist service.

Tirzepatide (Mounjaro) is recommended by NICE for eligible adults living with obesity who have at least one weight-related health condition, such as high blood pressure, type 2 diabetes, high cholesterol, obstructive sleep apnoea, or cardiovascular disease. Initially, NHS access through primary care is prioritised for those with the highest clinical need, generally a BMI of 40 or above, alongside four or more of these conditions. It is currently only available through specialist weight management services, with a phased rollout into primary care settings ongoing.

Both medicines are not recommended if you are pregnant, breastfeeding, or have certain health conditions. Eligibility can also vary depending on your local integrated care board, so it is worth checking what is available in your area. These injections are not available over the counter, and a healthcare professional will always need to assess whether they are right for you. If you are unsure where to start, speaking to your pharmacist is a good first step.

Our team at C&H Barton Pharmacy can help point you in the right direction. Call us today to speak with one of our pharmacists about your options.

What Results Can You Expect?

The results from clinical trials are encouraging. People using semaglutide (Wegovy) lost an average of nearly 15% of their body weight over about 16 months. Tirzepatide (Mounjaro) showed even stronger results, with some people losing over 20% of their body weight. Liraglutide (Saxenda) produces slightly more modest results, but still performs better than diet and exercise changes alone.

Weight loss tends to be gradual, and most people see the biggest difference after around 3 to 6 months. How much weight you lose will depend on things like your starting weight, how closely you follow dietary advice, and how active you are.

Thinking about your options? Contact our team at C&H Barton Pharmacy in Bedfordshire for a chat about what support is available to you.

Potential Side Effects

Like all medicines, weight loss injections can cause side effects. The most common ones affect the stomach and include nausea, vomiting, diarrhoea, constipation, and stomach cramps. These tend to be worst in the first few weeks while your body is getting used to the medicine, and they usually settle down over time.

In rare cases, more serious side effects can occur, such as inflammation of the pancreas or gallbladder problems. Anyone with a history of certain thyroid conditions or pancreatitis should not use these medicines. It is important to only use weight loss injections under the guidance of a healthcare professional.

–> Start at a low dose and build up gradually to reduce the chance of side effects.

–> Use your injection at the same time each week to keep the medicine working consistently.

–> Drink plenty of fluids, especially if you are feeling sick or have an upset stomach in the early weeks.

–> Eat smaller, lower-fat meals to help reduce nausea when you first start treatment.

–> See a healthcare professional if you get severe stomach pain, as this could be a sign of a serious reaction.

weight loss injections effect

Frequently Asked Questions

If you still have questions about weight loss injections in the UK, our most frequently asked questions are answered below.

Are weight loss injections available on the NHS?

Yes, some weight loss injections like Wegovy and Saxenda are available on the NHS, but only to people who meet specific eligibility criteria. Most people are referred through a specialist weight management service rather than getting a prescription directly from their GP. Waiting times vary, and not everyone will qualify. Private prescriptions are an option for those who do not meet the NHS criteria, though the cost can be high.

How quickly do weight loss injections start working?

Most people notice their appetite reducing within the first few weeks. Visible weight loss usually takes around 8 to 12 weeks to become noticeable. The dose is increased gradually at the start to help your body adjust, so the full effect builds up over time. Sticking with the treatment and making healthy lifestyle changes alongside it will give you the best results.

Do you put weight back on after stopping weight loss injections?

Many people do regain some weight after stopping these medicines, particularly if healthy habits have not been built up during treatment. This is because the medicine helps control the biological signals that drive hunger; when you stop taking it, those signals return. These treatments are generally intended for long-term use, and any decision to stop should always be discussed with a healthcare professional.

Can I get weight loss injections from a pharmacy?

Weight loss injections are prescription-only medicines, so a pharmacist cannot hand them out without a valid prescription. However, your pharmacist can be a great source of advice as they can help you understand your options, point you towards the right services, and support you once you have a prescription. At C&H Barton Pharmacy, we are always happy to have that conversation with you.

Are weight loss injections safe?

When used correctly and under medical supervision, weight loss injections are considered safe. They have been through extensive clinical trials and are approved by the MHRA in the UK. That said, they are not suitable for everyone, and a healthcare professional should always assess your suitability before you start. Never buy these medicines from unregulated websites — counterfeit products are a serious risk to your health.

What is the difference between Ozempic and Wegovy?

Both Ozempic and Wegovy contain the same active ingredient, semaglutide, but they are approved for different uses. Ozempic is licensed to treat type 2 diabetes, while Wegovy is specifically licensed for weight management and comes in a higher dose. Some people use Ozempic for weight loss, but this is considered off-label use. Your prescriber will help you work out which is most appropriate for you.

Weight Management Support in Bedfordshire

Weight loss injections can make a real difference for people who have found it hard to lose weight through diet and exercise alone. They are not without risks, and they are not right for everyone, but for those who qualify, they can be a genuinely helpful tool. Whether you want to find out more about your options, check whether you might be eligible, or just have a friendly chat about weight management, the team at C&H Barton Pharmacy in Bedfordshire is here for you. Get in touch today and let us help you take the next step.

Disclaimer: The content of this blog post is intended for general informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Weight-loss injections are prescription-only medications and must be used only under the supervision of a qualified healthcare professional. Always consult your GP, pharmacist, or a registered prescriber before starting any new treatment. If you experience severe or unexpected symptoms, seek urgent medical attention.
☑ Clinically Reviewed by Pharmacy Mentor
A pharmacist reviews the content to help ensure medicines are presented responsibly and that patient-facing health information is accurate, appropriate, and aligned with current clinical guidance.
Last reviewed: 27 April 2026
Written on behalf of C&H Barton Pharmacy by Pharmacy Mentor.